Iowa Heads West: Hawkeyes Face No. 20 USC in LA Showdown
Date: Saturday, Nov. 15, 2025
Kickoff: 2:30 p.m. CT (3:30 p.m. ET)
Location: Los Angeles Memorial Coliseum
TV: Big Ten Network
Line: USC -6.5 | O/U 49.5
Setting the Stage
Iowa’s defense meets Hollywood’s flash this weekend as the Hawkeyes travel to Los Angeles to face No. 20 USC in one of Week 12’s most intriguing Big Ten crossover matchups.
The Trojans bring one of the nation’s most explosive offenses—averaging nearly 40 points and 500 yards per game—while Iowa arrives with one of the stingiest defenses in college football, giving up just 13.7 points per game. Something has to give.
USC quarterback Jayden Maiava (2,614 yards, 22 TDs) leads a balanced attack that has found rhythm under Lincoln Riley. Iowa, meanwhile, continues to win with defense, special teams, and field position, ranking among the top 10 nationally in defensive efficiency despite an offense that averages only 309 yards per game.
Keys to an Iowa Upset
1️⃣ Control the Clock
Iowa’s best defense might be its offense—long drives and short fields. Keeping Maiava and company on the sidelines is crucial.
2️⃣ Force Turnovers
Phil Parker’s unit has made a living off takeaways. If the Hawkeyes can steal a possession or two, they’ll have a shot late.
3️⃣ Run the Rock
USC’s defense has improved but still gives up over 140 yards per game on the ground. Establishing the run early will open up play-action chances.
Keys for USC
1️⃣ Air It Out
Iowa’s secondary has been solid, but the Trojans’ speed and depth at receiver are on another level. Expect Riley to test the Hawkeye corners deep.
2️⃣ Start Fast
Playing at home, USC can’t afford a sluggish start. Getting ahead early would force Iowa to chase points—something their offense isn’t built for.
3️⃣ Protect the Football
Iowa thrives on mistakes. If the Trojans stay clean, they’ll dictate tempo and force Iowa out of its comfort zone.
What the Experts Say
Most oddsmakers have USC as a 6.5-point favorite with the total around 49.5. Analysts from CBS, ESPN, and FOX all point to USC’s offensive ceiling as the separator, especially at home against a limited Iowa attack.
Prediction
It’s strength vs. strength—and weakness vs. weakness. Iowa’s defense can keep this close, but USC’s ability to finish drives and create explosive plays should ultimately be the difference.
Final Score: USC 30, Iowa 20
Pick: USC –6.5 | Lean: Over 49.5
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